Try removing Java 6 update 2. Just have the 1 Java version installed on your computer.

Next, delete LW's preferences folder when LW's properly closed. See the thread below for instructions...remember to show hidden files & folders first, or you won't be able to find the preferences folder
LimeWire Pref Folder in Vista

Do you have Alcohol software installed? If so, check this thread.
http://www.gnutellaforums.com/genera...tml#post293318

You could also try right clicking on LW's desktop icon > properties > compatibility & run in compatibility mode for XP (sorry if that's not exactly the way to get to change compatibility in Vista...I use XP. It should be similar, though).