I've got exactly the same problem. I've tried all the solutions mentioned in the other threads. Reinstalling the security update, running the Java update, purging the incomplete downloads library, even the one on the Apple site using terminal, all to no avail. I suspect this may be a different problem. The common one seems to occur when installing OSX 10.3.9. I was already running 10.3.9 with no problems at all with Limewire. It was only when I updated to LW 4.10 that the problems started. The application opens ok and to start with everything works fine. Then it gets progressively slower until it can take minutes to respond to a mouse click and eventually Limewire quits. Any other applications running at the same time also slow down.