You should try submitting a ticket to trendmicro about the subject as well as posting here. It could be that for some reason it's blocking Limewire.

I don't think that many people use PC-cillin here as I have tried posting for Info on how efficient it is, because I was thinking of getting it for my PC.

Please post back when/if you get it fixed as I'm sure it will help many others as well.

Maybe someone has the answer here, but if you submit a ticket as well, you can be absolutely sure of an answer