I've had the same problem with 2.2.1 for the Mac. I've emailed tech support seeing as how I payed the $8.95 to buy the pro version. Their response was:

Have you tried the following though - go to
Tools->Options->Advanced->Port and change the value there to 10776 (or
some random number). Then hit OK/Apply and then try to connect.

Also, go to the connections tab and try to increase the amount of
connections you have.

Let me know if that works,
Zenzele T. Bell

Unfortunately neither of these suggestions did a thing for me. So, I responded and am waiting for a suggestion. Since the programmers have been fairly absent from the forums recently, I'll keep you all posted on any other suggestions they offer