I too am having the same issue. I was using LimeWire right up until Saturday May 31. Sunday I performed a defrag and since then LimeWire will not load. That's all I did... a simple defrag..the same one I've done for years on Sunday without a LimeWire hitch. Then suddenly...Click the icon..nothing, nada, zip.
I tried reinstalling it. When ever you click on the icon installation exe. file when. I'm in install hell, uninstall, reinstall hell.
I will try those "fixes" and bet I have an even deeper problem ensue.