Check points 5 & 6 also in the Fixes for LimeWire link Birdy gave you. If not work then ...
1. Did you try also reinstalling LimeWire? Go to Start Menu -> All Programs -> LW -> Uninstall. Then run either one or both of these utilities: (a)
Microsoft Windows Install Clean Up,
__ (b)
Crap Cleaner.
__ These will clean the system Registry for you.
2. If you have any LW preferences folder, delete it:
http://www.gnutellaforums.com/genera...der-vista.html
3. Then install 'this' OFFLINE version of LW
http://www9.limewire.com/download/LimeWireWin-full.exe
4. Remember for VISTA, you need to set the installer to Run as Admin I think, and probably the program also. If still opening issues, change compatibility mode of LW also as suggested at beginning.