There are a few more things to try here: http://www.gnutellaforums.com/331559-post2.html

Thanks for the reply, I have made some progress, I now get the User Account popup that an indentified program wants to run, and when I click "Allow" then nothing happens.

Are you using an Administrator account?

Did you try right clicking on LW's desktop icon > run as administrator?

I don't use Vista but I've heard that the UAC can be a pain.

I don't know what I did to solve the issue, but somewhere in between cleaning up my registry, reinstalling everything again, using different install folder names and whatever else I messed with, it is now fixed. Thanks all for the help.