I am getting the same error! I downloaded & installed the ISScript.msi from Limewire(It is hidden pretty well, but in the text for ERROR 160x it says get it from here(Click here)). THis did not solve my issue. I have a Personal firewall & Anti-Virus loaded - disabling them did not help. I also downloaded the JRE Enhancement - not to correct the issue, but to enhance the product. I am also configured to use VPN. Anyone have a solution to this issue?