Do you have another account on your computer? Try opening from there.

If you can access the preferences as in option > tools > Advanced >Performance, disable all those options.

I am having this exact same issue, I've tried everything, and still cannot get limewire to work. It closes down as sson as it gets to the screen that asks me where to save files.

No I do not have another account on my PC that is ever used except the guest account which is disabled.