I presume you mean you updated your LW to version 4.18.3 if so that means you have to reconfigure your firewall to accept LW once again -- have a look at this link hopefully it can help you (No Compromise” Vista-McAfee-Limewire Solution) if this doesn't work In Limewire Links (below) click on (system details) fill in and post back here

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Limewire links: (If LW 5 will not connect) (If LW 4 will not connect)(system details) (LW Clean Reinstallation Instructions) (setting up your firewall to accept LW)

LW links are changed at times to match the current problems.